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Acne: How to say goodbye to the marks teen acne is not always a disease; rather, it may be an inflammatory state transient natural that happens when the facial

No, acne is not a disease

Acne: How to say goodbye to the marks teen acne is not always a disease; rather, it may be an inflammatory state transient natural that happens when the facial

No, acne is not a disease
Acne: How to say goodbye to the marks

teen acne is not always a disease; rather, it may be an inflammatory state transient natural that happens when the facial skin mature are exposed to new microbes and increases the production of an oily substance called sebum, according to an article published today in the journal "Trends in Immunology". The authors argue that their study suggests that the development of new treatments should focus on promoting mechanisms that restore homeostasis –balance - in between the facial skin and their environment microbial and chemical.

"The main message is that, instead of considering acne as a disease accompanied by pathological processes, we propose that acne is nothing more than an inflammation inevitable, precipitated by physiological changes of the skin sebaceous during adolescence," says the first author, Andrea Szeged, of the University of Debrecen (Hungary).

acne vulgaris is unique due to its specific localization in regions of the skin rich in sebaceous glands producing sebum, its occurrence within a narrow range of age associated with puberty, their high prevalence in adolescents, and their resolution frequently

Among the various inflammatory diseases of the skin, acne vulgaris is unique due to its specific localization in regions of the skin rich in sebaceous glands producing sebum, its occurrence within a narrow range of age associated with puberty, their high prevalence in adolescents, and their resolution frequently. For example, the spontaneous remission of acne vulgaris occurs in up to 50% of affected patients, in contrast with other inflammatory diseases of the skin such as the psoriasis and rosacea, that have courses chronic intermittent.

Andrea Szeged - File

The team of Szeged is proposing however a new concept that might explain why acne is characterized by a strong regional specificity and age incidence and frequent resolution. Based in data immunological and dermatological , raise the hypothesis that sudden changes in the composition of the composition of microbiota within the skin rich in sebaceous glands during the adolescence, accompanied by an increased production of sebum can lead to an inflammatory response which replaces the microbiota-host homeostatic above, which leads to the manifestation of acne.

"Our hypothesis, which says that acne is a state of inflammation transient of natural development, instead of a pathological illness of the skin, challenges the conventional thinking," says Szeged-. This hypothesis incorporates data from recent science and can explain the features and special clinics for acne".

future research should focus on identifying how to resolve spontaneously acne, for example, through a reduced production of sebum, changes in the composition of strains of the bacterium, commensal, C. acnes, the regulation of the immune system of the skin, or a better integrity of the skin barrier

The authors cite evidence in mice shows that even a meeting to short-plaz or with new commensal microbes in the skin can start to build robust white blood cell T-lymphocyte that produce proinflammatory cytokines , including interleukin-17 and interferon-gamma. Also of note are the data of messenger RNA that show that acne lesions contain more pro-inflammatory cytokines characteristics of the interactions host-microbiota than healthy skin.

According to the researchers, future research should focus on identifying how to resolve spontaneously acne , for example, through a reduced production of sebum, changes in the composition of strains of the bacterium, commensal, C. acnes, the regulation of the immune system of the skin, or a better integrity of the skin barrier. "We are convinced that this research will be critical to the development of new and innovative treatments for acne," says Szeged.

"Moreover –he adds-, the mechanisms that initiate, amplify, resolve, or perpetuate the acne could have common pathways with diseases that develop in other organ systems, and the knowledge gained on a broader scale on this front can help to better understand a variety of diseases."

Publish Date : 26 Eylül 2019 Perşembe 21:03

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