Rams 1 point favorites over Bills in Week One. However, Bills are the favorites to win Super Bowl.

The 2022 NFL season will see the Buffalo Bills dominate the betting market.

Rams 1 point favorites over Bills in Week One. However, Bills are the favorites to win Super Bowl.

The 2022 NFL season will see the Buffalo Bills dominate the betting market. However, not always in the first game.

With odds of winning Super Bowl LVII at any major sports betting house, the Bills are the favorite with odds usually listed at +600 and +650.

The Buccaneers are the next most likely Super Bowl winner according to sportsbooks, with +700 and +750. Next are the Chiefs, at +900 to +1000. The defending champion Rams is at +1100.

The Rams are the 1-point favorite at most sportsbooks when they face the Bills in Week 1. As the defending Super Bowl champion, the Rams will be playing in this game as the home team.

The oddsmakers have the Packers listed at +1200 to win Super Bowl. They are followed by the 49ers, Chargers and Broncos at around +1600.

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