This was just the fifth biggest tournament in singles for Krejčíková, a 25-year-old from the Czech Republic.
She's the third unseeded women's champion in the previous five years in Roland Garros.
Krejčíková will now attempt to become the first woman since Mary Pierce in 2000 to win the French Open singles and doubles titles in the same year. Krejčíková and spouse Kateria Siniakova already possess two grand slam doubles titles and also are scheduled to play in the final of this event in Paris on Sunday.
The 31st-seeded Pavlyuchenkova was playing her first grand slam final in the 52nd big tournament of her profession.
She was treated for a left leg injury late in the second set Saturday.
She's the sixth consecutive first-time grand slam winner to collect the trophy at Roland Garros, in which the red clay could diminish the potency of speedy serves and the sometimes odd bounces made by, and special footwork required onthe surface can frustrate players.
Saturday's matchup between two first-time grand slam finalists was perhaps a fitting conclusion to a two months full of surprises.
Naomi Osaka, a four-time major champion seeded number two, withdrew after a match -- and a battle with grand slam officials above a rule that mandates speaking to the media -- to take a mental health break.
Australia's number one-ranked Ash Barty, the 2019 winner, retired from her second-round match with a left hip injury.
Number three seed Simona Halep, the 2018 winner, never revealed due to a hurt calf, while Serena Williams was beaten in the fourth round and defending champion Iga Swiatek lost in the quarterfinals.Updated Date: 12 June 2021, 13:46