Treccani and her colleagues studied in mice how stress at an early stage of life affects the reading of genes in a particular type of glial cell. As it turned out, there is a connection between the gene activities and the concentration of the stress hormone corticosterone. Upregulated was a gene that codes for a subunit of a voltage-activated sodium ion channel. Such channels play a role in the exchange of information between glial cells and nerve cells. In stressed mice, the current density in the ion channels increased. The activity of the gene in question was also increased in adult mice. At the same time, the brain power of these animals was limited.
However, not all mice were affected to the same extent. According to Treccani, this finding coincides with observations in humans: even in them, early childhood trauma would have different effects.
Link to publicationUpdated Date: 27 October 2021, 00:01