New therapy tested: With microRNA inhibitor against heart disease

A new therapy for cardiovascular diseases have been tested, researchers at the Goethe University, according to information from successful people. The scientists Stefanie Dimmeler were able to prove, therefore, for the first time that an inhibitor against a so-called microRNA effect.

In the case of the microRNAs are short strands of nucleic acids, which control many different biological processes. You can prevent the formation of proteins in cells or strengthen. In clinical studies, already microRNA were tested inhibitors to help against Hepatitis C or leukemia.

The Frankfurt-based team of scientists has tested a drug that targets microRNA 92a blocked in the blood. This nucleic acid plays in cardiovascular disease a role. You will be turned off, this encourages blood vessels the formation of new blood, improves blood circulation and strengthens the heart function, such as the clinical Trials showed. In addition, the used inhibitor accelerates wound healing and offers protection against the constriction and inflammation of blood vessels.

In the study, the French Institute of research Servier, and the American company miRagen Therapeutics were involved. The project was funded by the German centre for cardiovascular research.

Updated Date: 04 August 2020, 04:19