At a meeting of British-Irish Council Guernsey, politicians from the UK and Ireland will discuss recent political developments.
Taoiseach, the Irish Prime Minister Micheal Martin, and Conor Burns, the Northern Ireland Office (NIO), minister are expected to attend the summit.
Conor Murphy (Sinn Fein Minister) and John O'Dowd (Sinn Fein Minister) will be participating.
The Democratic Unionist Party, (DUP), will not be there as it continues its protest against the NI Protocol.
A spokesperson for the DUP stated that "The institutions aren't fully functioning." The protocol should be replaced.
It is the 37th British Irish Council summit, and the fifth time it was held in Guernsey.
This council includes ministers from both the UK and Ireland, as well as devolved administrations of Scotland and Wales, Northern Ireland, and leaders from Guernsey, Jersey, and the Isle of Man.
Spatial planning policy is the main theme of the summit, but discussions about the impending vacancy on 10 Downing Street will dominate the margins.
Michael Gove was expected to lead the UK delegation in Guernsey. However, he was fired by Prime Minister Boris Johnson on Wednesday night.
Nicola Sturgeon, the Scottish First Minister, has pointed out the absence of Gove via a tweet on Thursday.
Ministers will have the opportunity to learn firsthand about what could happen next, as the search for a successor for Mr Johnson begins.
Although it is premature to predict the future policy direction of the next prime minister, the Irish government has stated that it would like to see a more flexible position on post-Brexit trade arrangements and a rethink on legislation dealing Northern Ireland's violent history.
Along with Lord Caine, a fellow NIO minister, Mr Burns will be leading the UK delegation.
The Good Friday Agreement, which was signed in Belfast in April 1998, created the British-Irish Council two decades ago.
Its stated goal is to promote the harmonious and mutually-beneficial development of all relations between the peoples of these island communities.
The most recent summit took place in Wales in November.
The previous event was held in County Fermanagh, Northern Ireland. It was attended by Arlene Foster, the then-First Minister.
She broke into song at the post-summit conference and sang some lines from Frank Sinatra's That's Life.
She was just removed from the DUP leadership.
