Brunswick County Emergency Management said individuals were trapped in houses.
Ingram said hunts for lost individuals were penalized and will increase throughout the day. He has asked people to prevent the region while crews work to clean the roads and hunt for victims.
The Wilmington Fire Department tweeted it might send groups to help locate people missing following the tornado.
Brunswick Electric Membership Corporation said tens of thousands of people lost power.
"At least three fatalities, a range of accidents and harm to dozens of houses brought on by a ferocious tornado at Brunswick County last night," Cooper wrote on Twitter. "I've spoken with Sheriff Ingram and County Commission Chair Thompson, along with the nation has sent aid. Our prayers are with all."
A tornado in southwest Georgia also wreak havoc this feeble. On Monday, that an "extremely dangerous" tornado torn through numerous houses in Damascus, Ga..
A storm report relayed into the National Weather Service with a crisis mananger noted there was one injury and"significant" harm to some double-wide cell home and damage into some yearlong house.