Anne-Marie, Celeste, London Grammar, Wolf Alice, Mabel and Royal Blood are one of other's which are doing across the four times.
Five performances were filmed on location across the united kingdom in the front of legendary backdrops and will be shown that this weekend.
Coldplay will play at Whitby Abbey, while Ed Sheeran's operation occurs at Snape Maltings, a milestone arts complex on the banks of the River Alde at Suffolk.
Meanwhile, the AJ Tracey performs at The Regal, a basketball court belonging to South London community heart The Black Prince Trust.
Approximately 50 of those performances will be brand new live sets recorded exclusively for Big Weekend 2021.
Five performances were filmed in front of legendary backdrops across the united kingdom and others were recorded in the BBC's Radio Theatre.
Viewers will also have the ability to follow archive sessions from the Live Lounge and Piano Sessions as well as preceding Big Weekend performances.
Radio 1 DJs will be presenting the event in person and performances will be broadcast on Radio 1 with full collections available on BBC Sounds.